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It should be noted that the small percentage of participants (6.1% in the Harmony trial) in the subgroup with baseline SGLT-2i use may have reduced the consistency of the treatment effect estimates
The Journal of Clinical and Aesthetic Dermatology, 8 (4), 11-20
In research, this depends entirely on the study's objectives
Masking a diagnosis is the bigger risk: injecting B12 on top of an uninvestigated cause can hide the real reason for a deficiency and delay proper treatment
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